The contribution of the endocrine system to the development of osteoporosis in the elderly and senile (review)

Osteoporosis is increasingly found in the elderly and senile, maintaining its enormous medical social significance. The effect of hormones on bone metabolism beyond doubt. However, currently data sex tissue prevails. As for other hormones, sometimes, there are conflicting opinions. aim study: Based published data, to study contribution endocrine system development osteoporosis elderly. Materials methods: Literature was analyzed using following search words: osteoporosis, mineral density, FSH, estrogens, testosterone, cortisol, vitamin D, IGF1 1998-2020 computer databases PubMed, Scopus, Medical- Science, Elibrary, Web Ceeol. Results: Analysis literature showed that increase levels thyroid stimulating hormone (TSH) plays an osteoprotective role; decrease estrogen, insulin-like growth factor 1 (IGF1) as well parathyroid follicle-stimulating (FSH) contribute loss senile. In addition, FSH receptor (FSHR) genotype AA rs6166 associated with low regardless estrogen level. A polyclonal antibody FSHR-binding sequence against mouse ?-subunit likely be effective tool reducing mice subjected ovariectomy. Conclusion: comprehensive assessment hormonal profile senile needed identify causes formation individual program diagnostic rehabilitation measures. Currently, all prerequisites new therapeutic interventions correction density.